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KMID : 0391419960060020111
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Korean Journal of Lipidology
1996 Volume.6 No. 2 p.111 ~ p.116
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Lipoprotein(a) as an Acute Phase Reactant
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김치정
곽미향/김경만/유왕성/박종택/유언호
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Abstract
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This study was conducted to evaluate the property of lipoprotein(a)[Lp(a)] as an acute phase reactant. Lp(a) consists of low density lipoprotein and apolipoprotein(a), specific glycoprotein. It is generally accepted that high concentration Lp(a)
is
an
independent risk factor for cardiovascular disease. However, Lp(a) level cannot be lowered by nonpharmacologic and pharmacologic methods for hyperlipidemia. Although Lp(a) is though to be an acute phase reactant, there is still controversy, a
total
22
premenopasual women who underwent transabdominal hysterectomy with/without unilateral salphingoophorectomy were enrolled. Lp(a) and lipid profiles were measured before, at 1 week and at 1 month after operation. In contrast to other lipids, Lp(a)
concentration was elevated by 96.75 from 18.1±22.6mg/dL to 35.6±27.1 mg/dL at 1 week after operation. At 1 month, the concentration returned to basal level. Low density lipoprotein cholesterol was lowered only by 11.2%, and total cholesterol
and
high
density lipoprotein cholesterol decreased after operation. In conclusion, Lp(a) is thought to be an acute phase reactant and this property might be involved in the pathogenesis of atherosclerosis.
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KEYWORD
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